Computational Postdoctoral Fellow – Cowley Lab – 03327-R 

We are looking for a computational postdoc broadly interested in using machine learning approaches to answer  scientific questions about the brain. We focus on designing closed-loop methods for systems neuroscience as well as  building explainable computational models of neural responses and behavior. An important component of our work  

is to build tight-knit collaborations with experimental neuroscientists—collecting data and building models in  tandem. A long-term goal is to identify and understand the step-by-step computations in the brain. 

Computational Post Doc – Dobin Lab – 02145-R 

Join a team of biological data scientists working on novel statistical methods and computational algorithms for multi omics processing and integration, and leverage Big Genomic Data to elucidate various problems in precision health,  such as genetic and epigenetic mechanisms of cancer development and progression, and the clinical impact of  functional variants. 

Postdoctoral Fellow – Furukawa Lab – 03088-R 

The Furukawa lab has NIH-funded postdoctoral fellow/associate positions available for scientists interested in solving  questions in neurobiology and neuro-cancer-immunology by implementing a dynamic range of techniques including  structural biology (cryo-EM, x-ray crystallography, molecular dynamics) together with electrophysiology (patch clamp, slice physiology, lipid bilayer), protein engineering, chemical biology, mouse model, cellular imaging, and  cancer mouse model. underlying cognitive functions. 

Postdoctoral Fellow – Janowitz Lab – 02988-R 

The Janowitz Laboratory at CSHL is seeking a highly motivated, creative, and interactive postdoctoral researcher with  strong experimental and analytical skills to contribute to research on the connectivity of the host response to cancer.  We employ pre-clinical and clinical research to develop and test new treatment strategies and to discover  fundamental biological interactions between tumors and host organ systems. 

Joint Postdoctoral Fellow –Borniger Lab Janowitz Lab Lukey Lab 

– 03167-R. 

Together, the Borniger, Lukey, and Janowitz laboratory at Cold Spring Harbor Laboratory (CSHL) offer a unique  opportunity for a highly motivated and creative postdoctoral researcher, with strong experimental and analytical  skills, to investigate the reciprocal interaction of sleep and cancer progression. You will become part of a  multidisciplinary team of basic researchers and clinicians studying tumor-host interactions, using integrative  techniques from neuroscience, endocrinology, metabolomics, and immunology to dissect the mechanisms  connecting sleep disruption with aberrant metabolic and immune responses during cancer progression.

Postdoctoral Fellow – Joshua-Tor lab – 03123-R 

We are currently seeking innovative, inventive, and self-driven Postdoctoral Associates within the lab of Dr. Leemor  Joshua-Tor at Cold Spring Harbor Laboratory. The Joshua-Tor lab studies the structure and mechanism of gene  silencing pathways as well as DNA replication. To get a complete understanding of how these processes, the team  employs structural, biochemical, biophysical and molecular biology approaches to study how key proteins work at  the molecular level. More information can be found on their website.  

Postdoctoral Fellow – Jackson Lab – 03324-R 

A postdoctoral position is available to characterize the role of plasmodesmata in plant development, focusing on cell  to cell trafficking of the KNOTTED1/ STM class of homeodomain proteins and associated mRNAs. The position is  funded for 3+ years, and the candidate should have experience in arabidopsis molecular genetics and/ or cell biology/  microscopy. Our lab uses state of the art developmental biology, imaging and genomic techniques to understand  signaling in plant stem cell (meristem) development, using arabidopsis and maize as model systems.  

Postdoctoral Fellow - Kinney & Krainer Labs – Kinney Lab – 03307-R 

Justin B. Kinney and Adrian R. Krainer seek a postdoctoral fellow to spearhead a project focused on quantitative  signal integration in alternative mRNA splicing. This position is part of an ongoing collaboration between the Kinney  Lab and Krainer Lab, the goal of which is to quantitatively understand the readout of pre-mRNA sequence by snRNPs  

and RBPs, as well as the effects of splice-modifying drugs. The successful candidate will be expected to help design  their project’s aims, lead the necessary experimental work, and carry out the primary computational analysis of the  resulting data. These studies will primarily focus on splicing in human cell culture and/or in vitro splicing reactions,  

and will involve a combination of both low-throughput and high-throughput techniques, including massively parallel  reporter assays (MPRAs). Novel experimental techniques will be developed as needed. 

Computational Postdoctoral Fellow – Koo Lab – 03317-R 

The Koo Lab at the Simons Center for Quantitative Biology at Cold Spring Harbor Laboratory is looking to hire an  ambitious and self-directed postdoctoral fellow at the intersection of machine learning and genomics. Potential  projects include: 1) Bridge the conceptual divide between flexible deep neural network models and prior biological  knowledge of gene regulation by advancing the design concepts to provide an inductive bias towards biophysically  meaningful interactions. 2) Develop cutting edge model interpretability tools to distill knowledge learned by high  performing deep neural networks. 

Computational Postdoctoral Fellow – Koulakov Lab – 03057-R 

Cold Spring Harbor Laboratory is looking for outstanding candidates to fill postdoctoral positions in theoretical  neuroscience. The position is open under specific projects as well as general research involving the application of  methods from theoretical physics, mathematics, and machine learning with the goal to understand the brain  function. 

Postdoctoral Fellowships – Zhang Lab – 03248-R 

Dr. Lingbo Zhang’s Lab at Cold Spring Harbor Laboratory focuses on both basic science and translational medicine of  hematologic malignancies. The research of the Lab centers on normal and malignant stem and progenitor cells in the  hematopoietic system and decodes the role of metabolites in the tumor microenvironment in regulating hematologic  malignancies. Fully funded postdoctoral fellowships are available to investigate the roles of these critical metabolites  and their genetic effectors in hematopoietic malignancies and develop novel therapeutic strategies.

Postdoctoral Fellow – Martienssen Lab – 03249-R 

The Martienssen laboratory at Cold Spring Harbor has an opening for a postdoctoral fellow to study the mechanisms  of epigenetic inheritance in fission yeast and mammalian cells, recently funded by the National Institutes of  Health. RNA interference impacts inheritance and genome stability by silencing of repeats, as well as by non canonical means, and successful applicants will explore the role of epigenetic modifications, phase separation and  transcription-replication conflict in different developmental and cell cycle contexts. State-of-the art equipment and  facilities are available both within the lab and in outstanding shared facilities. 

Computational Post Doc – McCandlish Lab –02802-R 

Research in the McCandlish laboratory is focused on the analysis of high-throughput mutagenesis data, with the goal  of accurately predicting the phenotypic, health, and evolutionary consequences of both single and multiple  mutations in protein coding and regulatory sequences. The group has a particular emphasis on understanding  complex genetic interactions and the structure of the genotype-phenotype map. 

Postdoctoral Fellow – Moses Lab –03329-R 

CSHL invites applications for a Postdoctoral Research Fellow in Anticancer Drug Discovery. You will work on  collaborative projects between the Moses laboratory and cancer biologists at CSHL, focusing on novel strategies for  enzymes involved in cancer pathogenesis. You will be a crucial member of the Click Chemistry team based in the new  $75 million Center for Therapeutic Research (CTR). 

Postdoctoral Fellow – Schorn Lab - 03023-R 

We are interested in how small RNAs identify and silence transposable elements when they become active during  mammalian development and disease. This is an exciting new field with many opportunities! We believe tRFs are an  ancient link between RNAi, transposons and genome stability. 

Computational Post Doc – Siepel Lab – 02744-R 

A postdoctoral position in COMPUTATIONAL GENOMICS is available in Dr. Adam Siepel’s research group at the  Simons Center for Quantitative Biology (SCQB), Cold Spring Harbor Laboratory. 

The Siepel Group specializes in the development of probabilistic models and algorithms for inference, machine learning methods, and applications in large-scale genomic data analysis. Of particular interest is research relevant to  existing NIH-supported projects in: 

1. EVOLUTIONARY GENOMICS of humans and other mammals, including inference of ancestral recombination graphs,  detection of selective sweeps, comparative genomics of bats, inference of distributions of fitness effects and  quantification of genetic load from linked deleterious alleles; and 

2. TRANSCRIPTIONAL REGULATION in mammals, including quantification of initiation and pause-release rates from  nascent RNA sequencing data, characterization of elongation rates, and evolutionary analysis of transcriptional  regulation across primates and other mammals. 

Postdoctoral Fellow – Tollkuhn Lab - 03304-R 

The Tollkuhn Lab has an open position for a postdoctoral researcher to develop projects on hormonal regulation of  gene expression in the brain. The lab studies the transcriptional mechanisms of nuclear receptors in the context of  brain development, behavior, and disease. Gonadal hormones such as estrogen and testosterone are the principal  

regulators of sex differences in the vertebrate brain, but the regulatory strategies used by hormone receptors in the  brain remain largely unexplored. Our lab has recently published the first neural direct targets of estrogen receptor  alpha (ERα), and we now seek a colleague with expertise in gene regulation and the epigenome, who can expand on  this line of research.

Postdoctoral Fellow – Tollkuhn Lab - 03303-R 

The Tollkuhn Lab has an open position for a postdoctoral researcher to develop projects on hormonal regulation of  brain sexual differentiation. The lab studies how gonadal hormones such as estrogen and testosterone regulate brain  development, behavior, and disease. These hormones modulate the wiring of social behavior circuits during  developmental sensitive periods to produce sex-variable behaviors in adulthood. Our lab is seeking a colleague with a  background in neural development to explore how sex differences in gene expression give rise to sex-typical patterns  of neuronal connectivity. 

Postdoctoral Fellow – Tonks Lab - 03137-R 

Protein Tyrosine Phosphatases and the Regulation of Cell Signaling: from Basic Research to New Therapeutics. The  protein phosphatases are critical, specific regulators of signaling that serve an essential function, in a coordinated  manner with the protein kinases, to determine the response to a physiological stimulus. The Tonks Lab takes a  multidisciplinary approach to study the structure, regulation and function of the protein tyrosine phosphatase (PTP)  family of enzymes, to illustrate their fundamental importance to the control of signal transduction under normal and  pathophysiological conditions. As functional studies have established links to disease, the PTPs have been garnering  attention as potential therapeutic targets; however, they remain a largely untapped resource for drug development. 

Postdoctoral Fellow – Van Aelst Lab – 02796-R 

The main focus of research will be to study the roles of genes associated with human diseases in the development  and function of neural circuits, using molecular, genetic and viral engineering, optogenetics, imaging,  electrophysiology, and behavior analysis. 

Postdoctoral Fellow – Wigler Lab – 02822-R 

The Wigler and Levy research group are seeking a Computational Post Doc that will have a key role in a multi disciplinary team of wet-bench and computational researchers working to revolutionize cancer detection and  treatment by developing novel genomic technologies. We are re-envisioning the tools of genetics research by  

coupling innovation at the bench with novel computational methods. We have developed methods for inexpensive  copy number (SMASH), generating long reads from short-read sequencers (muSeq), encapsulation of cells in  acrylamide gel (BAG-seq), sensitive detection of cancer genomes (MASQ), and most recently mutational sequencing for short tandem repeats (muSTR). Applicants may review our most recent publications at  http://wigserv2.cshl.edu/doku.php?id=publications.  

Postdoctoral Fellow – Yeh Lab - 02869-R 

The Yeh Laboratory at CSHL Cancer Center (http://yehlab.labsites.cshl.edu) is seeking for a qualified postdoctoral  fellow passionate about biotherapeutics discovery and engineering. The Yeh Lab is a highly-collaborative  environment with state-of-the-art facilities and expertise in biotherapeutics engineering and chemical biology. 

Postdoctoral Fellow - International Brain Laboratory – Zador Lab - 03269-R 

The Zador lab has an opening for a postdoctoral fellow in neuroscience who will be part of the International Brain  Laboratory (IBL). The IBL (https://www.internationalbrainlab.com/) is a large-scale international collaboration in  brain research, which combines the efforts of approximately 50 scientists in 22 laboratories toward understanding  

the brain-wide basis of a mouse visual decision-making task. The overall goal of this postdoc’s project will be to relate  single neuron connectivity, gene expression and neural activity in the context of in the context of the IBL behavior, to  better understand the contributions of different neuronal types to the IBL task. Specifically, the project will involve  combining electrophysiological and imaging approaches (widefield and two-photon, including a mesoscope) with  new approaches for high-throughput circuit/genomic approaches (including BARseq and MAPseq)

To learn more about these positions and others available at CSHL follow us on Twitter @CSHLCareers or to apply,  please visit us at https://www.cshl.edu/about-us/careers/postdoc-positions/