The Yewdell Lab in the Department of Immunology at Genentech is seeking two highly creative  and collaborative Scientists to join a dynamic research team investigating the role of B cells and  antibodies in inflammatory and autoimmune diseases. The successful candidate will implement  

cutting edge technologies and methods in cellular immunology, molecular biology, genomics  and genetically engineered mouse models to advance exciting research stage programs into  early clinical development, as well as explore new areas of B cell biology ripe for target  discovery. Excellent communication skills are essential to facilitate fruitful collaborations with colleagues across a diverse array of departments, including bioinformatics, cellular and tissue  genomics, human pathobiology & reverse translation, early clinical development, and biomarker  discovery. 

Projects may include, but are not limited to: 

• Understanding the unique biology of long-lived plasma cells 

• Studying the function of tertiary lymphoid structures in inflammatory and autoimmune diseases (e.g. inflammatory bowel disease) 

• developing and/or applying novel technologies to study the genesis and development of  autoreactive antibodies across various immunological diseases (e.g. inflammatory bowel  disease, lupus, multiple sclerosis) 

WHO YOU ARE 

The ideal candidate will: 

• Have a PhD in a field related to cellular immunology. However, outstanding candidates  with diverse training (e.g. cell biology, biochemistry, molecular biology, developmental  biology, genetics) will be considered 

• Have a demonstrated track record of experimental and intellectual prowess as  evidenced by first or senior author publications in top-tier, peer-reviewed journals (Preprints also considered) 

• Be well versed theoretically and practically in cellular and molecular immunology  techniques including primary cell isolation from tissues, in vitro stimulation of  hematopoietic /immune cells, advanced flow cytometry, molecular biology, ELISA, qRT PCR/RNAseq/scRNA-Seq 

• Be able to independently drive a project by designing and executing experiments,  interpreting data, and making figures 

• Have exceptional critical thinking skills and an appreciation for rigorous, creative  negative controls 

• Be excited to work in a highly collaborative, dynamic research group with a dedication to  following the data wherever it may lead 

WHAT TO EXPECT FROM US 

• Starting salary ~135k 

• Amazing benefits, including health insurance and 401k 

• Access to state-of-the-art technologies, clinical data sets and samples • Campus-like lifestyle with a healthy work-life balance 

• Participation in seminar series featuring academic and industry scientists • Mentored opportunities to further develop professional skills 

Please contact yewdell.teddy@gene.com with any questions, thanks!