The Sharpe Lab at Harvard Medical School has created the CHIME (CHimeric IMmune  Editing) system for using CRISPR-based in vivo screening to discover novel cancer  immunotherapy targets. This project is performed by a multidisciplinary team of research scientists and research associates who conduct in vivo screens in preclinical murine  cancer models, validation/mechanism studies, and technology development centered on  in vivo perturbation of immune cells. The overall aim of this project to improve our  understanding of mechanisms of T-cell mediated tumor immunity. 

We seek a motivated, experienced, and creative immunologist to join our team as a  Research Scientist and lead a self-directed project that interfaces with these aims. The  candidate will pursue his/her own project within the group supervising existing research  associates working on this project. The candidate will also be responsible for leading  manuscript writing on their projects. Candidates must have a strong background in  immunology and cancer biology research, with experience in animal models required. 

The ideal candidate will also possess superior experimental planning, organizational, and  execution skills; an open mind; the ability to mentor and manage research associates; a  strong desire to collaborate and develop new technologies; and a proven ability to  efficiently and effectively solve problems. 

Harvard Medical School offers an outstanding working environment. The workplace  culture is exciting, collaborative, and supports a healthy work-life balance. Harvard offers  a comprehensive benefits package: https://hr.hms.harvard.edu/working-hms/benefits 

Principal Duties and Responsibilities 

• Develop, lead, and execute research projects independently 

• Lead manuscript writing on their project 

• Serve as the primary mentor of research associates working on their project • Stay up-to-date on literature and think creatively and critically about the project • Contribute to the lab through teamwork and discussion 

• Attend high-level meetings and report progress to funding partners through  presentations and progress reports 

• Present research internally at Harvard and externally at scientific meetings 

Minimum Qualifications 

PhD in relevant field (immunology, cancer biology, or similar) 

Extensive experience with tumor immunology preclinical models 

Demonstrated scientific contributions to the field with at least 1 first-author paper Applicants should send CV to Martin LaFleur at martin_lafleur@hms.harvard.edu