Biochemist, Receptor Discovery @ NextCure

February 13, 2020

Biochemist, Receptor Discovery

Job Description

NextCure is a clinical stage biopharmaceutical company located in Beltsville, MD, and focuses on the discovery and development of novel immunomedicines for the treatment of cancer and other immune-related diseases. We are seeking a highly motivated scientist with a strong background in biochemistry and molecular biology to join our Discovery Research team. NextCure employs multiple function-based screening approaches, termed Functional, Integrated NextCure Discovery for Immuno-Oncology (FIND-IOTM). We are actively developing screening platforms to target additional disease indications. Our goal is to identify novel, first-in-class therapeutic targets. A successful candidate will identify and validate protein-protein interactions to characterize ligand/receptor pairs responsible for mediating intercellular interactions identified by our functional screens. The selected candidate will work in a highly dynamic, proactive, multidisciplinary environment with the goal of rapidly moving novel biological immunomedicines toward the clinic.


  • Independently design and perform novel assays to isolate and characterize ligand/receptor pairs and protein complexes in the plasma membrane and extracellular space

  • Develop biochemical techniques and identify and compare platforms to facilitate receptor discovery

  • Draft research workplans on a target by target basis

  • Coordinate with other members of the NextCure team to validate the role of identified protein-pairs in

    mediating functional intercellular communications

  • Manage external collaborations with CROs and academic partners to compliment internal resources and

    to complete objectives in a timely fashion

  • Coordinate tasks across multiple projects and prioritize as appropriate

  • Communicate scientific results and conclusions in written reports and oral presentations

    Required education and experience

  • PhD in Biochemistry, Molecular Biology, or a related field

  • Postdoctoral experience preferred

  • Scientist level and compensation will be commensurate with level of overall experience


  • Extensive experience in biochemical and protein chemistry techniques (e.g. protein pull-down and crosslinking, chromatography and gel electrophoresis, ForteBio Octet or SPR, SEC-MALS, LC/MS, protein stability assays)

  • Hands-on experience with protein pull-down techniques

  • Experience with collecting and interpreting mass spectrometry-based proteomics data

  • Demonstrated ability to independently investigate, compare, and incorporate new techniques and


  • Outstanding project management, organizational and multi-tasking skills

  • Strong interpersonal skills, written and oral communication skills, and ability to work in matrix team


  • Strong publication record

    NextCure is an Equal Opportunity Employer and offers a competitive salary and benefits package in a scientifically engaged teamwork environment. Qualified candidates should email their resume to

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