Scientist/Sr. Scientist, Autoimmunity @ Rubis Therapeutics

March 16, 2020

Scientist/Sr. Scientist, Autoimmunity
DEPARTMENT Autoimmunity
LOCATION Cambridge

Rubius Therapeutics is a clinical-stage biopharmaceutical company that is generating red blood cells and engineering them into an entirely new class of allogeneic, off-the-shelf cellular medicines. Our Red Cell Therapeutics™ can potentially be used to replace missing enzymes for patients living with rare enzyme deficiencies, kill tumors in cancer and regulate the immune system for the treatment of autoimmune diseases. We expect to begin enrolling patients in our first clinical trial during the second quarter of 2019, which is evaluating RTX-134 for the treatment of phenylketonuria, an inherited metabolic disorder.

Additionally, we plan to file our first oncology IND for RTX-240 for the treatment of solid tumors by early 2020. In total, we plan to file four to five INDs during 2019 and 2020. We are proud of our passionate, high-performance culture – one based on a set of values that are the
cornerstone of who we are and how we hold ourselves accountable. Founded in 2013, we are based in
Cambridge, MA and currently expanding across all functions within the organization. Having completed our initial public offering in July 2018, (Nasdaq: RUBY), we are well capitalized to execute our vision of creating life-changing cellular medicines. Red blood cells are no longer just for carrying oxygen. Check us out at or follow us on Twitter and LinkedIn.

We are looking for a Senior Scientist/Scientist to join our Autoimmune group to help drive key
autoimmune programs. The candidate must be independent, goal oriented, technically competent and
able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly
motivated individuals, with deep scientific background in immunology, preferably autoimmune diseases,
who are comfortable working in a fast-paced entrepreneurial environment.
Work closely with a team of scientists in the Discovery teams to drive key autoimmune projects.
Design and execute experiments for non-routine in vitro immune assays, in vivo studies, and ex vivo
Phenotyping immune populations, sample preparation for in vivo studies, sample analysis.
Independent data analysis and proper electronic notebook record keeping.
Communication of experimental plans and data to multiple cross-functional scientific teams.
Support the continued protection, creation, and expansion of company’s intellectual property.
Assist in maintaining a strong, entrepreneurial and creative culture with a clear sense of urgency and
focus on providing transformational therapies to patients.
Experience & Qualifications
 Ph.D. degree in biology, immunology, biochemistry, bioengineering or related discipline and 2+
years of relevant laboratory experience, pharmaceutical or biotechnology industry preferred.
 Deep knowledge of immunology, preferably DC and T cell biology, and systematic approach to
understanding inflammatory and tolerance molecular mechanisms.

 Research background in autoimmune disease.
 Strong experimental skills, including tissue culture, isolation and culture of primary immune cells,
primary immune cell assays, flow cytometry, ELISA, and in vivo model development.
 Passionate about working at the bench to independently contribute to research directions and solve
challenging issues.
 Detail oriented, self-motivated, and comfortable working with highly technical projects and personnel.
 Ability to work on multiple projects simultaneously and deliver conclusive results.
 Highly adaptable and responsive to delivering for challenging commitments.
 Effective written and oral communication skills.
 Team oriented with strong work ethic.
Rubius Therapeutics is proud to be an equal opportunity workplace and is an affirmative action
employer. We are committed to equal employment opportunity regardless of race, color, ancestry,
religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender
identity or Veteran status.