Research Assistant @ Beth Israel Deaconess Medical Center Division of Nephrology

September 2, 2020
Research Assistant III- Beth Israel Deaconess Medical Center Division of Nephrology
Exciting opportunity to work on an academic/pharma drug discovery collaboration to treat kidney disease.
Conduct and help coordinate a variety of routine and specialized laboratory tests using molecular, cell
biology and/or biochemistry techniques, and animal models. The successful applicant will have previously
demonstrated a high degree of independence in conducting research projects and may have technical
expertise in specific area(s) that surpasses basic performance expectations. Understanding the theory
behind tests and procedures, performing lab procedures with speed and precision, and a high degree of
reliability are key attributes needed for this position. Work is performed in a multi-disciplinary, fast-paced
laboratory and requires excellent problem-solving abilities plus the ability to multi-task. Experience with
transgenic murine models preferred.
This position involves working on a research team under the direction of the Project Manager. Specific
responsibilities will include:
1.     Assisting the project manager in overseeing various aspects of the project and leading Research
Assistant I’s. This will involve the management and development of a large transgenic mouse colony, which
may include overseeing breeding, experimental planning, and generation of new transgenic lines.
2.     Designing, performing, and interpreting non-hypothesis based experiments using mouse and human
samples. Techniques may include single-cell RNA sequencing, proteomics, and metabolomics.
3.     Conducting hypothesis based experiments using pharmacology and genetic manipulation in transgenic
mice. Will assist in interpreting results and designing/performing follow up experiments.
Qualifications: PhD or Master’s degree with 2+ years’ experience
Department Description:
The Friedman and Pollak laboratories are in the Division of Nephrology at BIDMC/Harvard Medical School
and study genetic kidney disease, with a focus on focal segmental glomerulosclerosis (FSGS). Together,
these labs use multi-disciplinary approaches and a collaborative environment to uncover the etiology of
inherited kidney disease. Ultimately, the labs aim to make discoveries that improve therapeutic
interventions for kidney disease.
The Friedman and Pollak laboratories study inherited kidney disease using human genetics, transgenic
mouse models, and molecular biology. The labs are utilizing cutting edge techniques like CRISPR
mutagenesis, single-cell RNA sequencing, and super-resolution microscopy to understand how APOL1
mutations cause kidney disease in African Americans. The lab environment is highly collaborative and
meetings often include other nephrology labs, providing opportunities to learn new ideas and techniques.
To apply send cover letter and resume to