Be a part of the legacy: Postdoctoral Research Fellow Program
Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
What You'll Be Doing:
As a postdoctoral fellow in our Research Labs' Discovery Oncology group based in Boston MA, you will work with a highly collaborative team of scientists to design, develop and validate in vivo tumor models, ex vivo/in vitro assays and gene profiling to elucidate the immunological consequences of resistance to cancer immunotherapy at cellular and molecular levels. This work will enable understanding of the functional roles of adaptive and innate immune components in the context of tumor intrinsic and acquired resistance to different immunotherapeutic platforms.
Responsibilities include but are not limited to:
Employing in vivo mouse models to address questions salient to the mechanism(s) of resistance to tumor immunotherapy.
Performing immunophenotyping and gene profiling experiments using a variety of techniques including but not limited multiparameter flow cytometry and mRNA profiling, e.g. single-cell RNAseq.
Collaborating with internal and external scientists conducting in vivo tumor model studies to correlate and validate the in vitro assays.
Data interpretation, manuscript preparation, publication and presentation of results
Contribute to a safe and compliant laboratory work environment
What You Need:
Candidates must currently hold a PhD OR receive a PhD by fall of 2021. Degree should be in immunology, oncology, cell biology, or a related field.
Experience with mouse tumor model systems
Multiparameter flow cytometry of immune cells (mouse and/or human)
Proficiency in primary cell-based assays to test T and NK cell functions
Ability to conceive, design, execute and communicate complex experiments
Strong history of publication in peer-reviewed journals
Must be an independent and self-motivated scientist
It's Great If You Have:
Prior tumor immunology/Cancer immunotherapy experience
Molecular biology, bioinformatics (R studio, Python), genomics experience (CRISPR/Cas9)
Experience with viral immunology in a chronic infection setting (LCMV)
Human immunology experience
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.
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