Postdoctoral Position or Senior Research Scientist @ NYU School of Medicine

February 16, 2022

Research Project 

We are looking for highly motivated scientists with great communication skills, collaborative spirit and that love  for science. The projects will mainly focus on genome stability but are open to novel and unexpected  directions. 

The maintenance of a normal complement of the genome is a requirement for the success of multicellular  organisms. Aneuploidy refers to the presence of an abnormal (lower or higher than euploid) number of  chromosomes or chromosome arms (segmental aneuploidy). Although detrimental at the organismal level,  aneuploidy is extremely frequent (~90%) in human tumors (Beroukhim et al., Nature 2010).  

We recently conducted a  

combined analysis of  

point mutation and copy  

number data in primary  

human tumor samples  

and demonstrated that  

the distribution and  

potency of cancer driver genes on each chromosome or chromosome arm can predict the frequency of whole  chromosome or chromosome arm aneuploidy across cancers (Davoli et al. Cell, 2013; Sack, Davoli et al., Cell 2018). This suggests that the recurrent patterns of aneuploidy in cancer act as driver events during  tumorigenesis. Furthermore, through an analysis of genomics and transcriptomic data from primary human  tumors, we recently identified a negative association between the level of cancer aneuploidy and the extent of  tumor immune infiltrate, especially of cytotoxic T cells (Davoli et al. Science, 2017; William et al., PNAS 2021).  For example, in oral cancer, chromosome 9p loss predicts immune-cold phenotypes and resistance to  immunotherapy. Our ongoing research interest is to determine how cancer aneuploidy regulates the immune  microenvironment, utilizing a combination of experimental and computational approaches. 

What we offer 

Postdoctoral and staff scientist positions are available for a wet-lab project, a dry-lab project or a  combination of both. Applicants with a background in genetics/molecular biology and/or  bioinformatics are encouraged to apply. The Postdoctoral Researcher or Staff Scientist will have the  opportunity to receive training on the use of state-of-the-art cancer genetics approaches and genomics  analyses of patients’ datasets.  

Starting date: any time after February 2022. 


• PhD in molecular biology, genetics or bioinformatics 

• Strong research background in cell biology, cancer biology or genome instability 

• Strong publication record 

• Great interest and excitement for systems genetics and cancer 

About the new Institute for Systems Genetics @ NYU School of Medicine 

The Institute for Systems Genetics (ISG) at NYU School of Medicine was established in January 2014 by Jef  Boeke, PhD, with the mission of performing innovative science in the fields of systems biology and  genetics/genomics. We work closely with genomics and proteomics, and we partner with academic, research,  and industry organizations, including the New York Genome Center in Manhattan. 


Dr. Teresa Davoli;