Postdoctoral Fellow / Staff Scientist @ Massachusetts General Hospital

June 9, 2020

Project: Developing a system of human myeloid progenitor transfusions to address the problem of neutropenia in patients

 

Description:

  • Individuals with neutropenia (low neutrophil counts) are some of the most immunocompromised and at risk of fatal bacterial and fungal infections.
  • While the transfusion of red blood cells and platelets is commonplace, there is no effective and available white blood cell transfusion product.
  • The goal of this project is to develop a system of ex vivo expansion of myeloid progenitors and to characterize these cells in pre-clinical functional assays.
  • The ultimate goal is to develop a transfusable white blood cell product that could be commercialized and delivered to vulnerable patients.

 

The ideal applicant would have experience with:

  • Tissue culture
  • Retroviral and lentiviral transduction
  • Viability assays
  • Immunoblotting and ELISAs
  • Basic molecular biology techniques

 

The ideal applicant would be:

  • Highly motivated
  • Highly curious
  • Extremely well organized
  • Capable of mentoring a research technician
  • An excellent communicator

 

Duration: 2+ years

Potential applicants may reach out to David Sykes directly (DBSYKES@mgh.harvard.edu).