GlaxoSmithKline (GSK) is committed to developing medicines for global health challenges including respiratory, immuno-inflammation, oncology and infectious diseases. We know that finding cures means not just finding new drugs but finding new ways to discover drugs.
The Immunology Research Unit identifies and develops novel therapeutic targets for patients with unmet medical need, through leveraging strong genetic datasets, building drug hypotheses from output of functional genomic CRISPR editing screens and performing hands-on experimentation using a wide range of molecular and cellular techniques suitable for drug target identification and validation. Our Genomic Immunology group strives to explore that rich data landscape to derive crucial insight, and to integrate directly with our groundbreaking experimental science. This approach maximizes the probability of delivering successful clinical candidates, and ultimately helping people to do more, feel better and live longer.
The Investigator position will reside in the Genomic Immunology Group within the Immunology Department and will be based in Cambridge, MA. It requires a highly-motivated and skilled candidate to assist target identification and validation and to take part in the development of novel therapeutics for the treatment of immune disorders with high unmet medical need. This individual will work independently and/or in partnership with cross-functional project dynamic teams in a multidisciplinary matrixed environment to investigate the biology of novel immune targets using functional molecular genomic tools, to evaluate the effects of newly developed drug lead candidates on immune cell functions and to make significant and high-impact contributions in multiple GSK drug discovery programs.
- Identify and validate discovery targets using human genetics, single cell transcriptomics, cellular assays and/or inflammatory disease models.
- Design and perform molecular and cellular assays suitable for drug target identification and validation.
- Generate, analyze, interpret, present experimental results at various meetings to partners/collaborators and collaboratively plan experimental paths forward.
- Lead and/or support project teams in collaboration with scientists from multiple functional areas.
- Generate study reports and maintain a detailed record of experiments in electronic lab notebooks in accordance with company policy.
- Publish and present at national/international conferences.
- Share in responsibilities to support general lab functions.
PhD in Immunology, or related fields
- PhD with strong knowledge and research experience in the field of immunology and auto-immune diseases, such as such as inflammatory bowel disease, asthma, COPD, or atopic dermatitis, etc.
- Postdoctoral training preferred but not mandatory.
- Technical expertise in CRISPR, siRNA, multi-color flow cytometry, or mouse inflammatory disease models.
- Demonstrated track record of independent critical thinking and scientific achievement in research, exemplified by a strong publication record and/or significant contributions to a therapeutic development program.
- Strong verbal, written communication skills as well as interpersonal skills.
- Knowledgeable, highly motivated, creative, and collaborative.
- Learning agility and drive to continuously improve and develop.
- Previous drug discovery experience in a biopharmaceutical setting.