Biochemist @ NextCure

February 28, 2020
Biochemist, Receptor Discovery
Job Description
NextCure is a clinical stage biopharmaceutical company located in Beltsville, MD, and focuses on the discovery and
development of novel immunomedicines for the treatment of cancer and other immune-related diseases. We are
seeking a highly motivated scientist with a strong background in biochemistry and molecular biology to join our
Discovery Research team. NextCure employs multiple function-based screening approaches, termed Functional,
Integrated NextCure Discovery for Immuno-Oncology (FIND-IOTM). We are actively developing screening platforms
to target additional disease indications. Our goal is to identify novel, first-in-class therapeutic targets. A successful
candidate will identify and validate protein-protein interactions to characterize ligand/receptor pairs responsible
for mediating intercellular interactions identified by our functional screens. The selected candidate will work in a
highly dynamic, proactive, multidisciplinary environment with the goal of rapidly moving novel biological
immunomedicines toward the clinic.
• Independently design and perform novel assays to isolate and characterize ligand/receptor pairs and
protein complexes in the plasma membrane and extracellular space
• Develop biochemical techniques and identify and compare platforms to facilitate receptor discovery
• Draft research workplans on a target by target basis
• Coordinate with other members of the NextCure team to validate the role of identified protein-pairs in
mediating functional intercellular communications
• Manage external collaborations with CROs and academic partners to compliment internal resources and
to complete objectives in a timely fashion
• Coordinate tasks across multiple projects and prioritize as appropriate
• Communicate scientific results and conclusions in written reports and oral presentations
Required education and experience
• PhD in Biochemistry, Molecular Biology, or a related field
• Postdoctoral experience preferred
• Scientist level and compensation will be commensurate with level of overall experience
• Extensive experience in biochemical and protein chemistry techniques (e.g. protein pull-down and
crosslinking, chromatography and gel electrophoresis, ForteBio Octet or SPR, SEC-MALS, LC/MS, protein
stability assays)
• Hands-on experience with protein pull-down techniques
• Experience with collecting and interpreting mass spectrometry-based proteomics data
• Demonstrated ability to independently investigate, compare, and incorporate new techniques and
• Outstanding project management, organizational and multi-tasking skills
• Strong interpersonal skills, written and oral communication skills, and ability to work in matrix team
• Strong publication record
NextCure is an Equal Opportunity Employer and offers a competitive salary and benefits package in a scientifically
engaged teamwork environment. Qualified candidates should email their resume to