#  Special Postdoctoral Fellow, Cell Surface Receptors, Integrin Agonists, and Organoid Biology @ Harvard Medical School and Boston Children's Hospital 

 





September 05, 2025

 

 

Tim Springer, a leader in integrin biology, invites aspiring scientists to join his lab to advance groundbreaking research at the intersection of integrin signaling, organoid development, and cell surface receptor mechanobiology. A central focus of this role will be designing and applying integrin agonists to drive the growth and maturation of organoids, with wide-reaching implications for regenerative medicine, stem cell biology, and therapeutic development. This role offers mentorship and unique opportunities to establish a strong scientific foundation for launching an independent research career.

##### **About the Role:**

As a Special Postdoctoral Fellow, you will:

- Pursue cutting-edge research in areas such as:
    - Stem Cells and organoids: Develop and apply novel integrin ligands/agonists to promote stem cell and organoid growth
    - Cryo-EM: Activation of integrins and TGF-β, and ligand binding
    - Mechanobiology: Integrin force transduction in rolling adhesion and firm adhesion and TGF-β activation
    - Single Molecules: Utilize advanced techniques including FRET and magnetic tweezers to explore conformational change kinetics and force transmission in integrins and selectins
    - Innovative ReaLiSM: (Receptor and Ligand in Single Molecules) to study receptor-ligand binding dynamics
    - TGF-β Activation: Research localized activation at cell surfaces for new therapeutic targets
- Own and Develop Your Project: We encourage candidates to propose and develop their own research ideas, which they can carry forward to establish their own labs.

[Read more and apply here.](https://timothyspringer.org/news/2025/08/open-special-postdoctoral-fellow-position-2025)



 

 

 



 

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